微生物功能基因組學(xué)研究

Microbial Functional Genomics

黃留玉　王恒?擰? 史兆興　朱厚礎(chǔ)　蘇國富　

關(guān)鍵詞：微生物功能基因組學(xué), 藥物靶位, 疫苗, 生物功能圖譜

分類號(hào)：Q933 　文獻(xiàn)標(biāo)識(shí)碼：A

文章編號(hào)：0001-6209(2003)03-0432-07

　　自從1995年流感嗜血桿菌的基因組序列測(cè)定完成之后[1],目前已有75種(株)微生物的基因組完成測(cè)序,160多種(株)微生物的基因組測(cè)序正在進(jìn)行中[2].隨著各種微生物基因組測(cè)序工作的不斷完成和序列信息的積累,微生物基因組學(xué)研究的重點(diǎn)已由結(jié)構(gòu)基因組學(xué)向功能基因組學(xué)轉(zhuǎn)移.微生物功能基因組學(xué)研究不僅要闡明微生物基因組內(nèi)每個(gè)基因的作用或功能,還要研究基因的調(diào)節(jié)及表達(dá)譜,進(jìn)而從整個(gè)基因組及其全套蛋白質(zhì)產(chǎn)物的結(jié)構(gòu)、功能、機(jī)理的高度去了解微生物生命活動(dòng)的全貌,揭示微生物世界的各種前所未知的規(guī)律,并使之為人類和社會(huì)服務(wù).……

基金項(xiàng)目：國家重大基礎(chǔ)研究發(fā)展規(guī)劃(973)項(xiàng)目(G1999054103)和首都二四八重大創(chuàng)新工程項(xiàng)目(H010210360119)

作者簡介：黃留玉(1962-),男,河南省平輿縣人,研究員,碩士,主要從事基因工程及微生物學(xué)研究.Tel/Fax:86-10-83821044;E-mail:huangly@nic.bmi.ac.cn

作者單位：黃留玉（軍事醫(yī)學(xué)科學(xué)院生物工程研究所,北京,100071）　

　　　　　王恒?牛?軍事醫(yī)學(xué)科學(xué)院生物工程研究所,北京,100071）　

　　　　　史兆興（軍事醫(yī)學(xué)科學(xué)院生物工程研究所,北京,100071）　

　　　　　朱厚礎(chǔ)（軍事醫(yī)學(xué)科學(xué)院生物工程研究所,北京,100071）　

　　　　　蘇國富（軍事醫(yī)學(xué)科學(xué)院生物工程研究所,北京,100071）　

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微生物學(xué)報(bào)

ACTA MICROBIOLOGICA SINICA

2003 Vol.43 No.3 P.432-438